苏州大学唐仲英血液学研究中心pi招聘会应聘演讲-yb体育官方

应聘演讲1：

the role of cgmp-dependent protein kinase in platelet activation: the risk of taking viagra

li zhenyu md/phd

research assistant research scientist
department of pharmacology

university of illinois at chicago

usa

摘要：

the intracellular secondary messenger cgmp mediates signals by activating two types of cgmp-dependent protein kinases (pkg) (i and ii) differentially expressed in different cells. it is generally accepted that cgmp and cgmp-dependent protein kinase (pkg) play an inhibitory role in platelet activation. however, we have recently shown that cgmp plays biphasic roles in platelet activation: at low concentrations, cgmp stimulates platelet activation, and at high concentrations it inhibits platelet activation. physiological platelet agonists induced increase of intracellular cgmp levels. a specific inhibitor of phosphodiesterase (pde) 5, viagra, enhanced intra-platelet cgmp concentration and promoted platelet activation. we further show that the stimulatory effect of cgmp is mediated by pkg i and ii.

应聘人简介：

dr. li received his ph.d from suzhou medical college in 1997. he was a postdoctoral fellow in the department of pharmacology from 1999 to 2003, and promoted to research assistant professor in 2003. he received numerous awards and had many papers published in the top journals of his field, including cell, blood, and jbc, etc.

应聘演讲2：

dna vaccine for cancer immunotherapy: a practical approach

kuichun zhu, md, phd

research staff
the university of houston

houston, texas

usa

摘要：

cancers cause the deaths of millions of people annually, and seriously affect the lives of a lot more others. immunotherapy has emerged as one of the novel treatments in addition to traditional chemotherapy, surgical operation, and radiation therapy. dna vaccines have been proven to be effective and feasible in cancer patients. convenient and economic generation and modification of dna constructs, prolonged expression of whole antigenic determinants of tumor antigens of interest and costimulatory molecules make dna vaccine an attractive approach to be further explored and pushed for general clinical applications in cancer patients in the near future.

应聘人简介：

dr. zhu received his md from suzhou medical college in 1985, and ph.d. from oklahoma state university in 1997. after graduation, he worked as research associate, instructor, research scientist at baylor college of medicine, moffitt cancer center, md anderson cancer center in the fields of cancer biology and cancer immunotherapy. dr. zhu has about 20 publications in sci journals, including first author papers in blood, oncogene, vaccine, and cancer immunology immunotherapy.

应聘演讲3：

malignant tumor angiogenesis: mechanisms and anti-tumor angiogenesis of t2-tryptophanyl trna synthetase.

quansheng zhou md/phd

senior scientist
the scripps research institute

usa

摘要：

abnormal hype angiogenesis has been found in many malignant tumors. traditionally, vascular endothelial cells (ecs) have been considered to be key cells in tumor angiogenesis. recent researches of my team and other laboratories have revealed that tumor angiogenesis at early stage of malignant tumor growth is not mainly dependent on ecs; certain tumor cells and pre-cancer stem cells may form blood vessels. using our newly-established in vitro tumor angiogenic model, we have recently demonstrated that t2-tryptophanyl trna synthetase (t2-trprs) can specially inhibit tumor angiogenesis and found that pre-cancer stem cells abnormally express ve-cadherin and form vessel-like tubes.we have further identified a motif in ve-cadherin as the binding site of t2-trprs, unraveling the mechanism of specific anti-tumor angiogenesis of t2-trprs and revealing this motif in ve-cadherin as a new target for development of novel anti-tumor angiogenic drugs.

应聘人简介：

dr. zhou received his md and ph.d degrees from suzhou medical college in 1991, majoring internal medicine and hematology, and his mentor is famous professor ruan changgeng. he then worked at jiangsu institute of hematology for near two years and went to the u.s.a in 1993. as a visiting scholar, he got well trained in molecular biology at department of molecular biology, university of south florida. he did research at the blood research institute of southeastern wisconsin from august, 2004 to 2007 as a postdoctoral fellow. in 1998, he was appointed a scientist and a faculty of the scripps research institute and promoted to senior scientist in dec. 2006, and he has worked in the scripps research institute for near 10 years so far. in the u.s.a, he first cloned a novel gene named scramblase in the world and revealed important biological functions of the gene, and he has recently engaged in malignant tumor angiogenesis and pre-cancer stem cell studies. he received numerous awards and had 51 research papers published in the journals of his field.

招聘会时间：7月14日15:00 pm-20:30 pm

招聘会地点：苏州大学红楼115会议室

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